Breast cancer is a Malignant disease that has the highest against women. Management of breast cancer that is currently done is a combination of surgery and chemotherapy, because in addition to effective therapy, but also can extend the recurrence. Chemotherapy given a systemic therapy that has serious side effects, one of which the effects of myelosuppression. Leukopenia is a condition that requires proper treatment and immediately, because it can cause dose reductions and delays in chemotherapy. Medication is given on the condition of chemotherapy-induced leukopenia one of which is the provision of Granulocyte Stimulating Factor (G-CSF), but these drugs have side effects, and requires a high cost. Based on several studies, acupuncture is effective in treating conditions due to the effects of chemotherapy leukopenia, and give excellent results. Acupuncture can stimulate the formation of CSF thereby increasing the number of leukocytes in the blood and improve the function of hematopoiesis in bone marrow.