Preeclampsia is one of the causes of maternal death. The important factor of preeclampsia's pathophysiology is reduction of PGI2 as vasodilator. It causes vasoconstriction which influences the formation of desidua. Paracetamol is the most widely used antipyretic in the world. Mechanism of action of paracetamol may lead to preeclampsia. The aim of this research was to determine the relation between paracetamol used during pregnancy and preeclampsia in RS X Yogyakarta. The research was an analytical epidemiology with case control study design. Data were obtained from medical record and interview. Sample size was 137 maternal patients in October-December 2013 and 72 maternal have been followed up. Data were analyzed using descriptive statistics, Chi-square tests, and logistic regression. Preeclampsia patients were taking paracetamol during pregnancy (71.8%), aged 30-40 years (84.6%), and had preeclampsia family history (28.2) than non preeclampsia patient. Chi-square test showed the relation between paracetamol used (p=0.010, OR= 3.46 (95%CI= 1.30 – 9.22), dose a day (p=0.010, OR= 3.18 (95%CI= 1.12 – 9.06), duration of paracetamol used (p=0.005, OR= 7.75 (95%CI= 1.60 – 37.53), and used within first trimester (p=0.878, OR= 0.91 (95%CI= 0.26 – 3.12) to preeclampsia. Logistic regression analyses showed no correlation between variables to preeclampsia. Women who used paracetamol during pregnancy had an increased risk of preeclampsia.