The information system Point Of Sale (POS) is an information system designed and built to record sales transactions and process data in clinics and spa in Colony Amaranta to help accelerate the course of operations and service process from registration to payment process so that services can be improved. POS information system is built using the Waterfall method using Sequential Linear Model. Data collection techniques were interviews, observation, and literature study to analyze the needs of the POS information systems. The POS information system design using the Unified Modeling Language (UML) to describe the processes that occur in the information system. Diagram used in the development are use case diagrams, activity diagrams, sequence diagrams, and class diagrams. The programming language that used is PHP with CodeIgniter framework, and MySQL as the database. The results of the design of information systems are master data management form, customer registration form, transaction processing form, and management report form.. Keywords: Point Of Sale, Unified Modeling Language, Codeigniter, clinic and spa.