Two field experiments were conducted for two years (2013 and 2014) at the Multipurpose crop nursery of the University of Education, Winneba, Mampong-campus from May to September to evaluate the effect of three transplanting ages (30, 37 and 44 days) and four row spacing (30 x 30 cm, 40 x 30 cm, 50 x 30 cm and 60 x 30cm) on growth, yield and yield components of pepper. The experimental design used was a 3 x 4 factorial in randomized complete block design with three replicates for both experiments. The results showed that 44 aged transplants had the highest yield during the 2013 cropping season, tallest plant in both cropping seasons, highest number of branches and canopy width for the entire 2014 cropping season. The 30 aged transplants differed significantly from the other aged transplants in number of fruits per plant and widest fruit diameter during the 2013 cropping season. The 40 x 30 cm row spacing had the tallest plant and highest number of branches from 8 to 10 weeks after transplanting in both cropping seasons. The 30 x 30 cm row spacing differed significantly from the 50 x 30 cm and 60 x 30 cm row spacing in fruit yield during the 2013 cropping season. The 60 x 30 cm row spacing had the longest fruit length and the heaviest fruit weight per plant during the 2013 cropping season. It is concluded that for high fruit yield, farmers are to transplant pepper seedlings at 44 days using 30 x 30 cm row spacing.