Rust caused by Puccinia substriata var. penicillariae is one of the major disease affecting both forage and grain production in pearl millet. An attempt was made to manage pearl millet rust using plant product, bioagent and fungicides under screen house and field conditions. The experiment was conducted on susceptible hybrid HHB 197 both under screen house and field condition with eight treatments. Observation on rust severity recorded at grain filling stage. The experiment results indicated that all the treatments were effective in managing the disease but amongst them minimum disease severity (11.7%) and (21.7%) was contracted under screen house and field conditions respectively in treatment of Propiconazole 25% EC (0.1%) followed by Hexaconazole 5% EC (0.1%) and Copper oxychloride 50% WP (0.2%), Carbendazim 50% WP (0.2%), Mancozeb 75% WP (0.2%), Azadirachtin 0.15% (1500 ppm), Trichoderma viride (3%) treated pots and plot. Maximum grain yield (514.7 kg/acre), test weight (8.13 g) and Benefit: cost 3.98: 1 was observed in Propiconazole 25% EC (0.1%) sprayed plot followed by Hexaconazole 5% EC (0.1%) under field conditions.