Neem plant is considered as the most useful traditional plant in India. The various properties of different parts of neem tree are used as insecticide, antifeedant, hormonal, antifungal, antiallergic, antidermatic, anti-inflammatory, antiscabic larvicidal and spermaticidal activity etc. In recent era the major challenge is to increase the food production without harming the environment and can control the pest. Since, last decades pesticides have become an integral component in sustainable agriculture and the modern day cultivation practices uses of chemical pesticides and fertilizers are in eliminable. Enormous use of different chemical pesticides in agricultural fields is resistant to most of the pests. So that the natural pesticides from A. indica are considered to be less harmful, biodegradability, least persistence, lest toxic to non-target organism, economic and used to combat insects, pests are not ruled out. Neem derived products play an essential role in the pest management, in agricultural fields such as crop and stored grains. Fruitful results of application of formulated neem based products in agriculture field will provide a cost effective technology to the farmers.