The selection of vegetable tanning agents is important in tanning industry because they can generate environmental and economic impact. Environmental effect such as contaminating fresh water aquatic ecotoxicity and human toxicity is the problems of tanning industry. Based on economic aspect, the price and saving cost is the effect of the use of vegetable tanning agent. This research was conducted to analyze the impact of vegetable tanning agents selection based on environmental and economic aspect. To evaluate the impact of environment, the simulation software was used. The fuzzy multi-attribute decision making was also used to selection process to find the best vegetable tanning agents based on environmental and economic aspects.