The purpose of this study was to find out the different effect between the use Prezi and the use of Powerpoint as learning media towards the students' learning interest in Civic subject at class X IPS SMA Negeri1 Teras Boyolali. This was a quantitative study with experimental method that used treatment.The samples of this study were taken by using Simple random sampling technique. The design of this study was posttest-only control experimental. Data of this study were collected through observations and questionnaire. Data analysis precondition test was done by doing independent test, normality test, and homogeneity test, while Hypothesis was tested by using T-test.The result of hypothesis test found that tcount was 3,034 with significance level of 5% and df= n1+n2-2 (34+34-2=66), then ttable was 1,99656 (interpolation).So, tcount (3,034) > ttable (1,99656) and average score of experimental group 1 was 92,74, it was higher than the average score of experimental group 2 which gained 86,79. Based on the calculation, it can be concluded that there was a significant differences between the use of Prezi and the use of Powerpoint as learning media towards the students' learning interest to civic subject at class X IPS of SMA Negeri 1 Teras Boyolali 2016/2017 academic year.The use of Prezi as learning media give more significant effect to the students' learning interest since it had more innovative and interesting display, can be accessed online or offline, the given material was clear and easy to understand.