This research aimed at proving that the use of guessing meaning from context technique can improve the reading comprehension of grade XI students of M.A Alkhairaat Tomini. The researcher used true-experimental research design which involved experimental and control groups. The sample was selected by using cluster random sampling technique. The sample were class XI IPA as the control group and class XI IPS as the experimental group. Each class has 18 and 23 students. In collecting data, the researcher used non-test (observation) and test (post-test). The data were analyzed descriptively and statistically. Having analyzed the data, it reveals that there is a significant difference between the pre-test and the post test. In other words, the t-counted (6.552) is greater than the t-table (2.024) by applying 0.05 level of significance and the degree of freedom (df) of 39. It is concluded that guessing meaning from context technique can improve reading comprehension of grade XI students of M.A Alkhairaat Tomini.