Background: Thrombocytopenia is a condition of decreased in the number of platelets in the circulation. The disorder is associated with an increased risk of bleeding, even with only minor injuries or minor spontaneous bleeding.Objective: to analyze the effects of fish cork concentrate (Channa striata) on blood profile BALB / c mice with a model of cyclophosphamide-induced thrombocytopenia.Methods: Mice were divided into 6 groups (n = 3) all groups induced with cyclophosphamide at a dose of 100 mg / kg bw in sub-cutaneous for 3 days. Group I (control) were given distilled water in peroral. Group II was given Plasbumin ® 5% intravenously. Group III was given Pujimin ® (585 mg / kg bw) was orally. Group IV-VI were cork fish concentrate (Channa striata) at a dose of 100, 250 and 500 mg / kg bw in peroral, treatment for 10 days. Parameters measured were routine blood profile on day-1, the 7th, and the 11th, blood clotting time and absorbance bone marrow DNA.Results: Based on the results of the research that formed the model of thrombocytopenia with cyclophosphamide induction dose of 100 mg / kg bw on day-7, based on statistical analysis of cork fish concentrate (Channa striata) starting dose of 100 mg / kg bw can increase platelet although statistically not significantly different . For white blood cells, cork fish concentrate (Channa striata) dose of 100 mg / kg bw and 500 mg / kg bw increased white blood cell count was statistically significantly different to the cyclophosphamide group. For blood clotting time, cork fish concentrate (Channa striata) at a dose of 500 mg / kg bw were statistically significantly different increase blood clotting time against the cyclophosphamide group. For bone marrow DNA absorbance although the results were not statistically significantly different but the absorbance has a tendency to increase the provision of cork fish concentrate (Channa striata).Conclusion: cork fish concentrate (Channa striata) dose of 100 mg / kg bw able to improve the white blood cells and platelets in thrombocytopenia model induced with cyclophosphamide.