Implementation of student sheets activity in the learning process can facilitate students to understand the concept. Student sheets activity suitable for human heredity material is student sheets activity based on life skill. Based on this, the research aims to produce student sheets activity based on life skill in term of practicality. The development of the student sheets activity used 4-D model that consists of four steps. Those are define, design, develop, and disseminate. The disseminate was not conducted in this study. The practicality of the student sheets activity was determined based on the implementation, personal skill activity, and social skill activity. Based on the results of the implementation of that the student sheets activity was practically with average score of 97,65%, the personal skill activity with average score of 3,87%, and social skill activity with average score of 3,75 so that it practical and can used in the learning process. Keyword: Student sheets activity, life skill, practicality.