The aim of this study was to determine whether there is a relationship between hemodialysis frequency stress levels in patients with chronic renal failure undergoing hemodialysis at hemodialysis installation of dr. M. Yunus hospital Bengkulu City 2016. The study design used was a descriptive analytic method to explain each variable studied. The results showed that there was a significant relationship between the frequency of hemodialysis with the level of stress in patients with chronic renal failure, almost all respondents often undergo hemodialysis in hemodialysis installation in dr. M.Yunus hospital in Bengkulu city, of a total of 67 respondents almost half of respondents suffered moderate stress levels and no significant association between HD frequency with the stress levels of patients with CKD in Haemodialysis installation with p value 0.041 smaller than 0.05. The results of this study are expected to add insight and knowledge about the disease of CKD, and and is expected to continue this research in the context of a deeper and broader variables. Keywords: Frequency, Hemodialysis, Stress Levels.