Business ethics conducted by the Prophet Muhammad became interesting to be studied, he was living in Arab society patterned the jahiliyyah-an successfully applied ethical values. So it can reap a tremendous success. By looking at the background of the Prophet Muhammad's success in business, we should examine, firstly, the business ethics of Prophet Muhammad carried. Secondly, in the marketing sector that he did, because marketing is this form a business. The author uses a qualitative methodology with a historical approach. The author tries to uncover the historical facts behind the success of the Prophet Muhammad in business. Using the historical approach is expected to give an overview of business ethics and marketing practiced by the Prophet Muhammad. Using the historical approach has proved that; first, the Prophet Muhammad is a successful trader, the long process he has undergone as a guide for mankind to emulate his business ethics in his daily life. His experience as a trader of the Prophet Muhammad got long before he was sent by Allah swt to be Prophet and Messenger. And then from some experiences the Prophet Muhammad was legislated in the form of the word after he was sent. Secondly, In his practices he always upholds humanity and is not only worldly oriented. He always maintain the nature of honest, sincere, professional, silaturrahim and generous in all his activities, especially in business.