Late blight (Phytophthora infestans) is one of main potato diseases. Due to severe damage to late blight potato, crop will be cause lost of harvest up to 80%. Gene carriers of resistance to late blight known as the RB gene and have been incorporate into the genom of potato and produce transgenic potato. The objective of the research was to test six advanced transgenic potato clones for resistance to late blight (Phytophthora infestans). The research was conducted at Confined Field Trial at Citere Village, Pangalengan District Bandung (1,400 m above sea level). The experimental design was split plot. The main plot was spray with fungicides twice/week and was replicated three times. Subplot were 10 potato genotypes, consists of six transgenic potato hybrids, transgenic Katahdin SP951 as resistant check and three varieties of nontransgenic as susceptible check, i.e. Granola, Atlantic, and Katahdin. An experimental unit consists of 50 plants/plot, every treatment with three replicates. Plant observed were plant vigor, intensity of late blight damage, tuber yield component, and lost of yield. The result showed that there were no interaction of plant vigor and also all the treatmens were not significantly different. Transgenic potato clones of 20, 27, 65, 66, and Katahdin SP951 were resistant to late blight compare to check varieties of Granola, Atlantic, and Katahdin. The highest yielding at none spraying of fungicides were obtained from the resistance clones. Whereas, on the 20 sprayed fungicides all of the clones were high yielding. Tuber yield lossed ranged from 18,8–84,4%, the susceptible genotypes were also showed high losses. Clones 20 and 27 showed reletive high yielding and can be delayed application fungicides for period of 7 weeks after planting.