This study assessed improving hand hygiene compliance among health education students of Ambrose Alli University, Ekpoma, Edo State, Nigeria. Three research questions and one hypothesis guided the study. This study is a descriptive survey design. 200 education students of which all was Health Education in Ambrose Alli University, Ekpoma, Edo State was sampled out of the entire 4,987 population Faculty of Education students through a simple random technique. A questionnaire titled: Improving Hand Hygiene Compliance (IHHC) was used. Data collected were analyzed. The findings revealed that there was high level of compliance to hand hygiene among students Health Education students had positive attitude and knowledge on hand hygiene compliance and there was no significant difference on the attitude and knowledge of male and female Health Education students hand hygiene compliance. Based on the findings of the study, the following recommendations were made improved hand hygiene practice needs a multifaceted approach involving both individual and facility factors. This should include improved training programs and ongoing staff development. Most importantly, patients should be empowered to monitor those employed in their care. Poor or insufficient access to hand hygiene facilities also need to be addressed.