This paper reviews the potential sustainable agricultural bioindustry development based on animal feed and organic fertilizer through an integration between crops cultivation with livestock production. This bio-industrial development could be carried out successfully in Indonesia, including in the region of North Sulawesi Province. Cattle feed bioindustry could be developed from biomass of cassava plantation, such as the cassava leaves, tubers and cassava peelers. Whereas, the solid and liquid organic fertilizers bioindustry could be developed from cattle feces and urine. Agricultural bioindustry can be carried out in all areas of North Sulawesi Province, because almost in every district has beef cattle and cassava plants. The largest cassava production in North Sulawesi Province are in the regencies of Bolaang Mongondow, Sangihe Island and Talaud Island. Whereas the highest population of beef cattle are in the regencies of Bolaang Mongondow, North Bolaang Mongondow, Minahasa, North Minahasa and South Minahasa. Therefore, this type of bioindustry will be well implemented in the three regencies of Bolaang Mongondow, Minahasa and North Minahasa, as there are large cassava plants and with a high livestock population in these three areas. Although numbers of beef cattle population are also higher in some other regencies, but the production of cassava in those areas are still very small.