Cikapundung river is the sub river of upper Citarum River which was used by the people in Bandung city as a raw water for drinking water, irrigation and fishery. Cikapundung river that passes through many districts of Bandung have a great potential of being polluted by from domestic waste. This condition will affects the water quality of Cikapundung water. Having this condition, the urgency of conducting the research for measure the polution level at Cikapundung river was reasonable, with calculating the water quality status, the potential polutions domestic sector. Water quality status is determined by using pollution index method and potential pollution load of Cikapundung River using domestic polution emission factor approach. Result of pollutant index calculation Cikapundung River at 2016 in dry months has severe polluted water quality. Cikapundung watershed contaminated with domestic waste in the calculation of polluted pollutant potency in 2016 by 25.383,89 Kg / day TSS, 17,537.96 kg / day BOD, 18.461.01 kg / day COD, 889.97 kg / day N-Total and 96.92 Kg / day P-Total.