Cikijing River is part of Citarik Sub watershed over two administrative areas of Sumedang and Bandung regencies. Cikijing river become a discharge media by industrial activity and thus potentially cause pollution of river water. The purpose of this research is to analyze the impact of waste disposal of PT. X against 3 aspects ie cultivation, groundwater and soil quality and public health based on Government Regulation of the Republic of Indonesia Number 82 Year 2001. Cikijing River water quality in January and August 2017 contains parameters that do not meet stream standard these are TSS, TDS, BOD, COD, detergents MBAs, sulfur (H2S), oil and fat, nitrite, nitrate, and phenol. Pollution that occurred in the Cikijing River has no effect on the decline in soil fertility because the Cikijing River water is not used as a source of irrigation water for agricultural land in the sampling location. The analysis of clean water quality in the study sites was taken from 2 locations by comparing standard according to Permenkes RI. 492 of 2010. Water well parameters in Linggar village that do not meet the standard these are turbidity, Fe, Mn, and organic substances (KmnO4). While in Jelegong Village, turbidity, pH, Fe, Mn, and organic (KmnO4) parameters did not meet the quality standard. The quality of the well water at both sites of the monitoring point is not feasible for consumption should be processed first before being used for daily needs. The polluted Cikijing River is feared to reduce public health. Public health data obtained from government public health facilities in Cisempur, Sawah Dadap, and Rancaekek in the year 2015-2016 show that the disease suffered by many people, not as a result of water pollution Cikijing river.