Fish intestine and growth histological descriptions constitute the parameters which are a function of internal and external condition. The external factors include water quality, feed quality and feed quantity. Currently, grouper's growth is quite low, when in fact the protein content of its feed is high. The purpose of this study was to determine the effect of simplicia papaya on histological description that affects the growth Epinephelus lanceolatus fuscogutattus. Grouper's absolute weight and grouper's protein efficiency ratio which is fed with Simplicia papaya-added feed. The research is conducted using Completely Randomized Design with 5 treatments and 3 repetitions (A: simplicia papaya 5% application, B: simplicia papaya 3.75% application, C: simplicia papaya 2.5% application, D: simplicia papaya 1.25% application, and E: 0% simplicia papaya). The grouper cultivation is done in a Floating Net Cage in Pangandaran Regency. The addition of simplicia papaya at 3.75% and 55 to the grouper's artificial feed has some influence in number of necrosis cell of 169 and 183, and the number of goblet cell too. The addition of simplicia papaya at 5%, 3.75% and 2.5% of the grouper's artificial feed has some increasing absolute gain by 161.36 grams, 152.19 grams, 152.09 grams. The addition of simplicia papaya at 5%, and 3.75% of the grouper's artificial feed has some increasing in protein efficiency ratio by 3.18% and 3.19% respecttively.