Drought is very influential towards the growth and production of the potato crop. A crossing to drought-tolerant genotypes was conducted and continued with a progeny selection. The aims of this study were to study the response of the potato plant to drought stress and to select potato clones resulted from conventional crossing for drought tolerant. The genetic materials tested were 78 progenies resulted from drought selection in 2015. The study was conducted by comparing plants in drought and normal irrigation conditions in the Greenhouse of the Indonesian Vegetable Research Institute, Lembang, in 2016. Results showed that drought stress affected potato growth as well as tuber yield. On drought conditions, potato plants tend to be poor of plant vigor, showed wilting symptom, yellowing leaves and roll up of the leaves. Drought stress caused the decline of stem diameter of (41.4%), main stem number (6.63%), plant height (22.43%), canopy diameter (18.76%), leaf area (53.7%), per plant tuber number (17.54%), per plant tuber weight (70.35%), tuber length (44.45%) and tuber diameter (42.85%). Another response to drought was the increasing level of proline and chlorophyll in leaf. Based on morphological character changes, vegetative growth and tuber production, 26 genotypes demonstrated potential drought tolerance. The selected genotypes will be used to the next selection in the field to get stable drought-tolerant potato clones. The availability of drought-tolerant potato clones can respond to the threat of reduced potato production due to climate change.