Factors Influence the Sustainability of Small Medium Micro Enterprises in Bandung and Bogor. Small Medium Micro Enterprises (SMEs) provide a huge contribution on economic. In line with the global economic, the competitiveness among enterprises rises. SMEs have low competitiveness caused by low quality, limited innovation and technological mastery. To have the competitiveness and business sustainability, SMEs are required to respond rapid technological innovations, focus on long-term interests, produce environmentally friendly products and strive for natural resource conservation as well as efficient use of technology. Factors supporting business sustainability need to be improved on business activities to support the sustainability of SMEs. This study aimed to analyze the profile factor, external environmental support, utilization of ICT facilities and competence that affect the sustainability of the business. This study used survey design with sampling technique disproportioned stratified random sampling to 358 respondents in four research sites. Data were collected through data collection questionnaire and done in 2017. Data was analyzed using descriptive techniques and Structural Equation Models (SEM). The results showed the level of MSME sustainability in urban areas was higher than in the district. City of Bandung and City of Bogor with sub variable income and business growth had score percentage higher than Bandung District and Bogor Dictrict. This is shown in product quality as well as better innovation. Factors affecting business sustainability are the perceptions of SMEs and ICT utilization factors, which directly affected business sustainability. One variable of ICT utilization is more effective to increase ICT adoption among SMEs business actors.