The aim of this study was to compare the effectiveness of autogenic relaxation and music therapy to the level of pain in HD patients when insertion of vascular access. This study used Quasy experiment study with Post Control Only Control Group Design, which was conducted on 99 HD patients with total sampling. The results, using independent t test analysis, showed that there were similar pain levels in each group. There was no difference in the effectiveness of pain levels between HD patients who were given autogenic relaxation with HD patients who were given music therapy when access insertion (p value = 0.896, alpha = 0.05). The average level of pain in the music therapy group is (5.00), autogenic relaxation with an average level of pain (5.27) and the average level of pain in the group combined between autogenic relaxation and music therapy namely (5.06) . Music therapy has a low level of pain compared to autogenic relaxation because during music therapy does not require a large mental effort for the patient to remain in focus. Keywords: Hemodialysis, Pain Level, Autogenic Relaxation, Music therapy.