SThe purpose of this study is to influence service quality and trust in loyalty with patient satisfaction as an intervening variable at the Syifa Medical Center Clinic. The data used in this study are primary data obtained from the results of questionnaires. The sample in this study is 100 outpatients, with the sampling technique using purposive sampling. The data analysis technique used in this study is Structural Equation Modeling-Partial Least Square (SEM-PLS) using SmartPLS version 3 software. The results show that there is an effect of service quality on loyalty, there is an influence of trust on loyalty, there is an effect of patient satisfaction on loyalty , there is an influence of service quality on satisfaction, there is influence of trust on patient satisfaction, service quality influences loyalty through patient satisfaction, trust influences loyalty through patient satisfaction.