Science and technology have great benefits for mankind. But science can also be a punishment for humans. In other words, science has positive and negative values for humans. Efforts need to be made to minimize the negative side of science and increase its benefits, so that science is present as a blessing for the universe. Science that is rahmatan lil ‘alamin is a science that can implement the values of rahmatan lil ‘alamen thus bringing humanity to a life that is prosperous, safe, peaceful and egalitarian. Such science is expected to bring harmony to life. Not only brings prosperity to humans, but also to all beings on earth. Efforts to present the science of rahmatan lil ‘alamien are carried out with science learning integrated with rahmatan lil ‘aalmaien Islamic values. Science learning that rahmatan lil ‘alamin has several characteristics, among others: presenting a non-pragmatic intention in learning science, linking faith to God with natural phenomena, science learning is contextual, science learning is associated with values, culture and beliefs. The implementation rahmatan lil ‘aalamin science learning requires the hard work of all parties considering the current reality of science learning still oriented towards the West. This is due to the lack of concrete examples of learning models and alternative science books.