HIV (Human Imunnodeficiency Virus) is a virus that attacks the human immune system and then causes AIDS. Statistics of HIV AIDS cases reported in Indonesia by the Indonesian Ministry of Health states that the cumulative number of HIV infections up to as many as 108 600 people in June 2013 and the cumulative number of AIDS from 1987 - June 2013 as many as 43 667 people. One important step is tackling HIV AIDS PLHA to improve adherence to antiretroviral drug taking. ARV therapy success rate is highly dependent on the level of compliance of PLHA. Expected with a high degree of compliance can increase the number of people living with HIV CD4. This study is a quantitative analytical design that aims to determine relationships ARV compliance with the rise in the number of people living with HIV in CD4 Lancang Kuning Support Group Pekanbaru 2014. Study was conducted in January-May in Lancang Kuning Support Group Pekanbaru, using primary data with a population of 30 people, a sampling technique that the total population. Instrument research using questionnaires, data processing univariate frequency distributions are presented in the table, followed by bivariate analyzes are presented using the chi-square test. Results reveal that the majority of respondents do not obey ARVs by 22 people (73.33 %) and the majority of respondents experienced an increase in CD4 cell count 27 people (90%). From a statistical test with chi-square test found no relationship adherence consume ARV with the increase in CD4 cell count of PLHA. Suggestions for administrators to be able to motivate members to improve compliance guidance antiretroviral therapy.