Overfishing has an impact on decrease of fish stocks so that it affects status of fish resource management. This research aims to analyze the optimal utilization of skipjack resources in the waters of Moluccas. Primary and secondary data were obtained through interviews and official publications. Data were analyzed through surplus production model with the techniques of CYP, and continued with the analysis of the bioeconomic model of Gordon Schaefer. The results showed that at the management regime of MSY, skipjack production reached 61.461.26 tons, with fishing effort 50,295 trips. At the open access regime, efforts increased to 84,836 trips with declining of production to 32,475.32 tons. Compared to both the MSY and open access, resource management regime at the MEY contributed to a higher economic rent, Rp 327,868,123,7700, but a lower fishing effort of 42,418 trips, and production 59,953.41 tons. Based on the bio-techno-economic values, the management regime of MEY was classified as the optimal utilization of the skipjack resources.