This study aims to look at how the learning pattern PAI and Muhammadiyah University Makassar Pare-Pare, with mengoprasinalkan deskriktive Qualitative methods. The data collection is done by interview, observation and documentation, research found that curriculum Islamic Religious Education (PAI) and AIK Al Islam and Kemuhammadiyahan) in Unismuh Makassar and Unismuh Pare-Pare; both based curriculum Higher education has been determined. Kepmendiknas Nomor 232/U/2000 Kepmendidnas No.045/U/2002. Competence is defined as "a set of intelligent action, the full responsibility of a person as a condition to be considered capable by the public in carrying out tasks in certain occupations". Related to the autonomy of universities in developing curricula, KKNI (Criteria for National Qualifications Indonesia, Association of Prodi PAI Muhammadiyah universities, learning patterns AIK between Unismuh Makassar with Unismuh Pare-Pare in common in terms of the curriculum (Objectives, Structures, Materials) The difference is only in terms strategies / approaches and methods. Unismuh characteristics of Pare Pare and Makassar Cultural Propagation Dakwah Community. Factors supporting its output has the potential and the opportunity to preach in community. Faktor its reference resistor required rigid inflexible because only by the Legal Affairs Committee Decision. Thus, an important part of University of Muhammadiyah take referrals eyes Lecture creed in this case Worship particularly the practice of prayers using references other than the decision of the Legal Affairs Committee, so that the knowledge the students a broader and does not cultivate an understanding of fanatic Muhammadiyah, which menebabkan insight into students narrow in worship and truth claimed that himself alone the most correct.