This article is intended to explain PKI movement in South Sulawesi in 1950 – 1965. The main subject in this research is to know how the dynamics of the movement of the PKI in the middle of the bad political situation and regional security. Is there any dynamic interrelation relationship and mutual influence between the PKI with other political group? How does PKI offset local forces so that they can withstand before its destruction in 1965? This reasearch is important to overview the changes and the power relations in the middle of dynamics politics of South Sulawesi. The research method that is used in this rearch is critical history method with doing documentation source analysis and in depth interview. The result found that the rebellion of DT/II of Kahar Muzzakars and Permesta affected the rhytm of PKI movement. PKI could not evolve the organization in rural areas because of the penetration of DI / TII in the countryside that was spreading anti-religious agitation of PKI. Meanwhile in the city, PKI got challenged from the military and elite bureaucrats who were generally dominated by nobles. As a result, PKI failed to gain support in the South Sulawesi in 1955 elections. After DI / TII and Permesta exterminated, the PKI movement was growing rapidly and had a wide support from the peasants. There is a dynamic relationship interrelation, fluctuating, mutual influence between PKI with other political groups from one period to another period.