The Apostle Paul is one of the great theologians in the New Testament who are rich in theological thought. One result of his thinking is about the significance of the cross for human life. The author views this research as important, because it will further clarify the significance of the cross for human life. Formulation the problem in this study is how is the significance of the cross for humans in Paul's theology? The purpose of this study is to explain the significance of the cross to humans in Paul's theology. While the method used by the author is to use the literature reset. The results of the study show that in Paul's theology the cross has great significance for human life, because the cross is the power of God that saves mankind, a place of exchange of punishment, guaranteed freedom from curses, and a place of reconciliation.