Introduction: Patients with terminal kidney failure report limitations and physical changes, psychological functions, weaknesses that have a negative effect on health status and a decrease in survival. Progress in dialysis technology and disease management still raises many complaints both physically and psychologically by increasing the mortality rate of patients undergoing hemodialysis. In 2008, there were about 1.75 million patients worldwide who regularly received kidney replacement therapy in the form of dialysis, about 1.55 (89%) million underwent hemodialysis (HD) and around 197,000 (11%) used peritoneal dialysis ( PD) Purpose: This study is to explore the experience of hemodialysis patients with physical changes and emotional turmoil. This research is a descriptive qualitative research that aims to reveal broadly and deeply about the causes and things that influence the occurrence of something. Method: exploration is carried out with the aim of digging deeper into the existing elements to obtain specific information that influences the pattern of life behavior of patients from aspects of sexuality. Results: The results of the study found two categories of themes, namely: (1) Physical changes and physical complaints: black facial skin, damaged teeth, thin body, weak body, and fatigue quickly. (2) Feeling and emotional turmoil is felt: not accepting and fearing death, feeling helpless and useless, apologizing and suggesting that the couple remarry. Conclusion: the exploration experience of physical changes and emotional turmoil of hemodialysis patients is influenced by physical, physiological, psychological, social and spiritual aspects as well as values, cultures that exist in the lives of participants.