The purpose and objectives of this work were to study the nature of the heart, lungs and kidneys angiopathy in rats with a model of systemic autoimmune disease, carrying out comparisons of the results with extravasal morphological manifestations of the pathological process, the state of vascular endothelial function and activity of pro-inflammatory cytokines in the blood. The experiment was conducted on 40 non-linear rats. To simulate the disease animals were injected by complete Freund's adjuvant, a solution of splenic deoxyribonucleic acid cattle, mercaptopurine, methyluracilum and with food rats constantly received sulfate cadmium, lithium hydroxybutyrate and ammonium molybdate. Within two months from the start of the study animals were taken out of the experiment on the background of intraperitoneal nembutal anesthesia. Histological sections of the heart, lung and kidney tissue were stained with hematoxylin -eosin, alcian blue and by van-Gieson, becoming the PAS-reaction. In the animals with the proposed experimental model of systemic autoimmune disease observed morphological characteristics of lesions of the heart blood vessels, lungs and kidneys, the nature of the manifestations of which were interconnected with each other, which confirms the common pathogenetic angiopathy constructions at various diseases in clinical practice. In the genesis of cardiac, pulmonary and renal vessels lesions act the activation of pro-inflammatory cytokines and violation of vascular endothelial function, which has a certain practical significance. In clinical practice, not only purely systemic vasculitis, and other autoimmune diseases should be treated as angiopathy.