Acceleration of the reparative process of bone tissue after surgical interventions is an urgent issue in surgery and dentistry. One of the methods for replacing lost bone tissue is using an osteoplastic material. There is a question in the choice of better material, which will meet all the requirements of the doctor and fully perform its function. This work studies the activity of reparative processes of bone tissue in rats when the titanium screw is screwed into the femur using synthetic osteoplastic material Klipdent PL with membrane Klipdent MK (“Vladmiva” Russia) and Easy-graft material with Hyprosorb (“Sunstar” Swiss) membrane. The obtained results were compared with a control group in which the similar manipulation was performed without the use of an osteoplastic material. The experimental and morphological study was carried out. Conclusions are drawn about the effectiveness of the materials under study.