.Fructose is a natural ingredient that is widely used as a sweetener substitute for glucose. Effectiveness and efficiency are the main reason so many industries use fructose to be consumed. Dosage is based on the toxicity of fructose consumption is divided into: a low-dose, medium-dose and high dose. It said consumption of high doses when someone is 100g / day or more. Many products it does not include the type and quantity of sugar fructose in food and beverage packaging and lack of knowledge lead to uncontrolled fructose consumption in developed countries. Consequences of uncontrolled doses can lead to liver disorder and others tissue. The liver is the organ forming fatty compounds as a homeostatic mechanism. Fructose is based on theoretical and experimental likely responsible for the formation of steatosis. In the organoleptic inspection on the provision of high doses of fructose seen their fat droplets are large, which indicates steatosis. Nevertheless still needed histopathology for diagnosis. Additionally duration of fructose to animals try to be more prolonged (> 2 months) to see the response to the homeostasis of the body fat is formed.