The objective of the research is to find out the influence of International Pre-service Teaching Program toward students' speaking English ability at Makassar Muhammadiyah University. The researcher applied descriptive qualitative research. The population of the research was the students who join International Pre-service Teaching Program (P2K International) at Makassar Muhammadiyah University. The researcher used total sampling technique. The population consisted of 15 students who joined in 2014 and 13 students who joined in 2015. The result of the research data showed that there were 25.31% students chose Strongly Agree from 237 items in positive statement and 37.14% Agree, 27.85% Undecided, 5.90% Disagree, and then 3.80% students chose Strongly Agree. While 1.57% students chose Strongly Agree from 254 items in negative statement and 10.24% Agree, 21.26% Undecided, 23.63% Disagree, and then 43.30% students chose Strongly Agree. In self-confidence aspect they feel no worry anymore to speak in public, in grammar they can not deny that their grammar become better, in fluently their English speaking is not slow as beginner, and their vocabulary significantly enriched after the program. All these aspects lead the students to become speaker especially in English. Having analyzed the data, it can be concluded that Pre-service teaching International program has significantly influence and improved the students' English speaking ability at Makassar Muhammadiyah University.