Indonesia is a developing country with a high population growth rate, along with the increasing population in Indonesia, the competition for jobs is getting more competitive, while the job opportunities offered are limited, so it demands young people and students to be more creative through entrepreneurship. Entrepreneurship education began to be taught in schools, both high school and university, including at the State Islamic Institute of Lhokseumawe. This teaching is expected to be able to motivate and increase student interest in entrepreneurship. This study aims to determine the effect of motivation and attitudes partially and simultaneously on entrepreneurial interest using quantitative methods. Sampling using purposive sampling technique. Data collection was carried out by distributing online questionnaires as many as 92 students as respondents. Data processing with multiple linear regression testing. The results showed that (1) Motivation was able to influence interest in entrepreneurship in FEBI IAIN Lhokseumawe students, (2) attitudes were able to influence interest in entrepreneurship in FEBI IAIN Lhokseumawe students, (3) motivation and attitude were simultaneously able to influence interest in entrepreneurship in FEBI IAIN Lhokseumawe students. Keywords: Motivation, Attitude, Entrepreneurial Interest.