The article discusses the results of drawing up a set of measures to ensure the safety of personnel working with chemically hazardous facilities. It was revealed that the storage and transportation of potent toxic substances is often the cause of accidents at chemically hazardous facilities. It has been shown that much larger volumes of potent toxic substances are contained in the warehouses of enterprises. It has been determined that in case of accidents in the workshops of the enterprise, in most cases there is a local contamination of the air, as well as the equipment of workshops, the territory of the enterprise. As a result, an emergency situation is possible when infection, mainly of production personnel, can occur. In order to eliminate predicted accidents, a set of measures has been proposed to ensure the safety of personnel and equipment of chemically hazardous facilities. The classification of potent toxic substances is presented.