Team-Based Learning (TBL) is one of the new instructional strategies that encourage a higher level of learning and cognitive skills; it is a type of evidence-based collaborative active learning. Team-Based Learning is a form of small-group learning that enables one instructor to manage a number of small groups in a large class at the same time. So, small groups can work independently and effectively in the knowledge application under faculty leadership although the high students to faculty ratio. The four principles of TBL are properly formed and managed groups, student accountability, team assignments that promote learning and group interaction, and frequent and immediate feedback to the students. However, there some obstacles and challenges that prevent the successful application of Team-Based Learning in medical education such as shortcomings of the content and the lack of qualified and experienced tutors. Thus, it should overcome these barriers during implementation to ensure effective Team-Based Learning. It should establish collaboration among faculty members, administrators, and other stakeholders based on a shared vision. Moreover, organizing regular training sessions which involve faculty members is by providing the required different resources, besides assigning a responsible educational team to implement the Team-Based Learning process with a regular follow-up.