Acute Organophosphorate Poisoning: Clinical, Diagnostic and Therapeutic Approach
2021
Rafael Medina Lucero, Juan Farak Gomez, Mauricio Diaz Carrascal, Juan Castilla Ortega, Oscar Sanchez Andrade + 1 more author

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Abstract

Organophosphate poisoning is considered pesticides that have the ability to inhibit the enzyme Acetylcholinesterase to produce an overstimulation of muscarinic and nicotinic receptors present in the CNS, exocrine glands, hollow organs, among others. A narrative review was carried out based on keywords of poisoning, organophosphate, poison and acetylcholine in between 2015 and 2020. Organophosphate poisoning mainly presents in cholinergic syndrome product of overstimulation of the muscarinic receptors. Subacutely, it can present as intermediate syndrome and subsequent consists polyneuropathy induced by organophosphates. The clinical findings pesticide exposure will provide the diagnosis. In the driving initial symptomatic should use atropine, which will act in a competitive with ACh for muscarinic and nicotinic receptors, but the reversal of the action of the organophosphate on AChE is only carried out with the oximes, pradiloxime is the first choice. The reviewed provides updated information about key aspects in organophosphate poisoning as well as a approach in the clinical presentation.

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