The ancient manuscripts of the Archipelago are a cultural heritage of the past whose contents are of high value, not only for the present but also for the future. One of the manuscripts that has contemporary significance for the people of the archipelago is the Ma Huwa Asasul Jamiatul Muhammadiyah manuscript which was obtained from an ancient manuscript collector named Ginanjar Sya'ban who lives in the city of Bogor. This study was carried out with the hermeneutic paradigm as a humanities science, namely the science that carries out the heurmenetic function by placing text as a social discourse. Text analysis, especially single manuscript editions, was carried out by using descriptive analysis method. This method assumes that the handling of the Ma Huwa Asasul Jamiatul Muhammadiyah manuscript needs to be analyzed carefully by considering the specific cases in the text and the nature of its intertextuality. Based on the results of the analysis of the Ma Huwa Asasul Jamiatul Muhammadiyah manuscript, cases were found. In the manuscript of Ma Huwa Asasul Jamiatul Muhammadiyah explained the main reasons why KH Ahmad Dahlan founded Muhammadiyah in the city of Yogyakarta in his sermon in the city of Pekalongan in 1340 H/1921 AD. used in the Qur'an. This shows that the Ma Huwa Asasul Jamiatul Muhammadiyah manuscript is a document for the spread of Muhammadiyah teachings during the Islamic era in Java. The purpose of this study is to provide information about the establishment of the Muhammadiyah organization contained in the manuscript.