To be able to grow and produce, palm oil requires the use of the factors of production optimally. This research aims to determine the factors that influence palm oil production in regency of Mukomuko Province of Bengkulu. Studies conducted in the Selagan Raya District and the District XIV Koto Mukomuko Regency in July 2012. Research area is selected purposively with 80 farmers selected as respondents with consideration whose have an oil palm growers have produced (plant age over 3 years). Data was collected through survey methods such as primary data and secondary data. The primary data is obtained through information collected from respondents using a structured questionnaire in a structured (questionnaire) covering the identity of respondents, institutional, land and livestock, as well as the accessibility of the area of oil palm production factors. And the secondary data is obtained from the Central Statistics Office and related institutions. The data obtained were analyzed by using a model of Cobb-Douglas production function which is processed by the analytical techniques OLS (Ordinary Least Square). The results showed that the factors affecting the palm oil production in the Mukomuko regency is the age of the plant significant positive rate of 37.90% and outpouring of labor sigbificant positive rate of 66.00%.