Antibiotics are the ' wonder medicines ' used for battling microbes. Numerous types of antibiotics have been not only used for therapeutic purposes for decades, but have been used prophylactically across other fields such as livestock and animal husbandry. The emergence of multidrug resistance among pathogenic bacteria jeopardizes the importance of antibiotics which have transformed medical sciences before. A growing list of infections, i.e. pneumonia, tuberculosis, and gonorrhea, is becoming more difficult and sometimes impossible to treat as antibiotics become less effective. Antibiotic-resistant infections are correlated with antibiotic intake levels. It is mainly the non-judicial use of antibiotics that makes the bacteria immune. Extensive efforts are required to reduce the rate of resistance by researching emerging microorganisms, mechanisms of resistance and antimicrobial agents. Multidisciplinary strategies are required across health care environments, as well as across sectors of the environment and agriculture. Conservative new approaches including probiotics, antibodies, and vaccines have demonstrated positive results in future trials that suggest the role of these alternative options as preventative or adjunct therapies.