Purpose: The aim of this review study is to outline rheumatoid arthritis and VEGF participation in rheumatoid arthritis disease development and also to help future researchers in this field.
Study Design: A Review Study.
Subjects and Methods: A number of research articles were systematically reviewed. More sixty research studies related to rheumatoid arthritis and the role of VEGF Gene were examined. The results of these studies are highlighted and compared.
Results: Rheumatoid Arthritis is capable of causing joint damage, moreover, lead to long term disability in severe cases. Mutation in VEGF due to the involvement of multiple factors (environmental, genetic factors etc) lead to severity in RA patients as it has a role in certain inflammatory processes, angiogenesis etc. Further research needs to be done in this field because many of the factors involve in pathogenesis of RA such as factors that cause loss of tolerance and inflammation in joints, are still unclear.
Conclusion: Although old diagnostic techniques are optimized, we further need to improve the diagnostic and treatment techniques in order to diagnose the patients at early stage. This will pacify patients' disease severity and provide certain preventive measure that will assist in preventing the aggravation of disease in family members.