. This paper sheds a new light on the strategies to foster student's entrepreneurial skills by administering creative thinking infusion learning as the learning framework in a biology classroom. Creative thinking infusion learning is construed as bringing or showing the stages of creative problem solving's thinking of student thinking in the classroom. To assist student engaging with the infusion in the classroom, we utilised creative thinking diagram to generate entrepreneurial ideas that apply the concept of Biology in solving a problem. Student's entrepreneurial skills were gauged by six creative entrepreneurship indicators. To investigate those indicators, this paper administrated one group pre-test post-test design and mixed-method approach by using diagram thinking, questionnaires, reflective essays, and interview. The analysis did not show any significant impact of the creative thinking infusion learning towards entrepreneurial skills. This result was demonstrated by no significance differences were seen in the sixth indicators.