. The purpose of this development is to develop androbiocation learning media based on SETSI (Science, Environment, Technology, Society and Islamic integrated) and HOTS (Higher Order Thinking Skill) in the coordination system material and test the feasibility of androbiocation that has been developed. The method used to develop androbiocation learning media is Research and Development (R&D) with the ADDIE model (Analyze, Design, Development, Implementation and Evaluation) which was developed by Robert M. Branch in 1975. In this study using formative evaluation, namely the results of the assessment of the media carried out at each stage so that they can know the quality. The results showed that the androbiocation learning media that was made was very suitable to be used as a learning medium. Media assessment is based on experts and students, namely material experts 85 percent (very decent), media experts 91 percent (very decent), integration experts 100 percent (very decent), and biology teachers 93 percent (very decent), and finally students' class XI SMA gets a percentage of 90 percent (very decent).