Self-efficacy in relation to environmental literacy is an individual's assessment of one's own ability to take attitudes and actions that they believe are correct to solve environmental problems. Environmental literacy aims to increase human awareness of the environment through positive attitudes and behaviors in interacting with the environment. This study aims to determine the differences in self-efficacy and environmental literacy of students majoring in Mathematics and Natural Sciences at SMA Negeri 9 Malang. This study uses a quantitative approach with a descriptive type of research. The samples used in this study were students of class XI and XII majoring in Mathematics and Natural Sciences and Social Sciences at SMA Negeri 9 Malang. The sampling technique was done by stratified random sampling. The instruments used are self-efficacy and environmental literacy tests. The results showed that there were differences in the average self-efficacy scores of students majoring in Mathematics and Natural Sciences, namely 65.8 and 62.8, while the average environmental literacy test scores were 278.95 and 257.97.