—Influenza is caused by a rapidly mutating virus that consists of 2 types, namely, type A with the H1N1 and H3N2 genotypes and type B. Influenza caused global mortality with 250,000-500,000 death in 2009. The effectiveness of vaccines also changes regarding the mutation of influenza viruses, however, the development and utilization of influenza vaccines should be supported by the economic status of a country. Up to now, many countries have not prioritized the utilization of influenza vaccines. The target of influenza vaccination in children and adults (> 60 years old). The purpose of this review was to determine the effectiveness of influenza vaccines from various countries and categorize them based on their income. This review used Medline, Elsevier, and BMC Public Health as the database with the keywords "Effectiveness" and "Influenza vaccine". Then, the articles are selected based on inclusion and exclusion criteria. Based on the initial search 784 articles match the keywords, and only 13 articles met the criteria. These articles are classified based on the center of the study to classify based on their national income; 5 studies in high-income countries, 5 studies in upper-middle-income countries, 3 studies in lower-middle-income countries, and 1 study in low-income countries. The results showed that the administration of influenza vaccine in high-income and upper-middle-income countries is quite effective for type A H1N1 genotypes, whereas H3N2 is less effective. In the lower-middle-income countries, the utilization of vaccines with type A H3N2 genotype was effective, however, in the low-income countries, the effectiveness of vaccines has not been justified due to the limited study of the type of influenza and the administration of influenza vaccines in those countries.
Keywords: effectiveness, high-income countries, influenza vaccine, low-income countries, middle-income countries