Terahertz (THz) radiation has properties that make it more attractive and effective in the field of biomedical imaging techniques. This is because THz radiation does not ionize and damage tissue. This study used a sample of bovine biological tissue, namely skin, fat, tumor and muscle tissue. The aim of this research is to find out whether a tissue is indicated as abnormal or normal by looking at the heat mapping generated from the absorption of THz radiation in the biological tissue of cattle by means of modeling. This study uses biophysical computation techniques with the simulink-matlab method. The range of THz radiation frequency used is 0.1 - 1 THz, power 50 - 150 mW and power density 5 - 25 mW / mm3. The ratio and temperature of each tissue were fat 0.25 T / 25 oC (T = 6.25 oC), skin 0.432 T / 25oC (10.8 oC), muscle 0.675 T / 25oC (16.88 oC) and Tumor 0.9 T / 25oC (22.50 oC). The results showed that fat tissue has less heat production and a lower temperature than skin and muscle tissue. This is because the fat tissue has a high water content with a more dilute concentration so that more THz radiation is absorbed with energy that runs out Faster according to tissue penetration.