. The number of smokers in Indonesia continues to increase although anti-smoking campaigns are often carried out to prevent people from smoking. In each campaign, various anti-smoking messages are conveyed through various media. This raises the question, how far can anti-smoking messages be trusted and how much do smokers desire to quit smoking? This study investigates four variables that are thought to influence an individual's desire to stop smoking, namely: (1) Demographic factors: age, education, and income; (2) Trust in campaign messages; (3) Attitudes towards campaigns, and; (4) Frequency of smoking. This study uses a survey method involving 695 respondents who smoke in the Greater Jakarta area. Data analysis was performed using correlation statistics, standardized multiple regression, and hierarchical multiple regression. The analysis shows that demographic variables including age, education, and income have a significant influence on the trust in the contents of campaign messages, and attitudes towards anti-smoking campaigns. The frequency of smoking is also significantly related to the three demographic variables studied. In the end, all four variables showed a significant influence on the desire to stop smoking where smoking frequency was the variable that had the greatest effect (R2 = 22%), followed by the level of trust and attitude that showed almost the same contribution (R2 = 21% ) and finally demographic variables showed the smallest influence to the smoking cessation variants (R2 = 1.3%).