Inflation is one of the effects of a prolonged economic crisis that hit the country. Inflation is a situation where there are price rises sharply (Absolute) which continues over a period of time. The purpose of this study analyzes the monetary policy conducted by Bank Indonesia and its influence as the money supply, interest rates and exchange rates SBI (IDR / USD) of the inflation rate. The method used is multiple linear regression based on test results indicate avariable effect on money supply, interest rate of SBI, and the exchange rate (Rp / USD) in 2004 to 2009. By using eviews 4.0 software obtained from the results of research following the money supply and exchange rate (Rp/USD) had no significant effect on inflation while the interest rate (SBI) have a significant effect on inflation.