. Dengue virus infection not always cause dengue hemorrhagic fever in humans because it depends on other factors, one of which is the immune system that affected by nutritional status and age. This study aims to determine the relationship of nutritional status and age on the dengue virus infection status. The study was conducted in Cirebon regency with cross sectional design. The height and weight was measured and body mass index (BMI) was calculated to determine the nutritional status. The results are grouped into two categories, abnormal and normal. Age groups are determined based on the interview, then grouped in the < 5 years and > 5 years age groups. Examination of blood samples using a rapid diagnostic test to find out the status of dengue virus infection. The resulting data, then analyzed to determine the relationship between nutritional status and age group with the status of dengue virus infection. The respondents was 200 persons consisting of 86 men and 114 women. Respondents with abnormal nutritional status is 68 respondents (34%) and 132 (66%) was normal; in < 5 years age group there is 193 respondents (96.50%) and 7 respondents (3.5%) in < 5 years age group. Blood examination showed 39 respondents (19.50%) with positive dengue virus antibody and 161 respondents (80.50%) is negative. Bivariate analysis showed the nutritional status and age groups are each associated with dengue virus infection status, with age group as the most influential. It was concluded, nutritional status and age group shown to be associated with dengue virus infection status. Abnormal nutritional status and age group < 5 years are a risk factor for the transmission of dengue virus.